New roles for TRPM7

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The Pathophysiologic Roles of TRPM7 Channel

Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and its channel activity is negatively regulated by free Mg(2+) and Mg-complexed nucleotides. Recent s...

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ژورنال

عنوان ژورنال: Nature Reviews Immunology

سال: 2008

ISSN: 1474-1733,1474-1741

DOI: 10.1038/nri2467